retention and effective diffusion of model metabolites on

Determination of the diffusion coefficients of small

In cheese technology, the mass transfer of small solutes, such as salt, moisture and metabolites during brining and ripening, is very important for the final quality of the cheese. This paper has the following objectives: (i) to review the data concerning the diffusion coefficients of solutes in different cheese types; (ii) to review the experimental methods available to model the mass

Analytical Methods for Quantification of Drug

2011/11/30Another effective way to resolve the retention issue is to add ion-paring reagent into mobile phase. The formed neutral ion pars increase retention and also improve peak shape. Among different ion-paring reagents trifluoroacetic acid and other perfluorated acids for basic analytes and for instance nucleoside phosphates for acidic analytes are appropriate for LC-MS/MS analyses [ 79 ].

Retention and Effective Diffusion of Model Metabolites on

2017/12/29The effective diffusion properties of these columns were studied using peak-parking experiments with the standard metabolites under a wide range of retention conditions. Under the high retention conditions, which can be associated with retention after injection loading for gradient separations, D eff / D m ~ 0.1 for both the C18-bonded and porous graphitic carbon columns.

A novel individual

Background and purpose: Effective drug delivery in the avascular regions of tumours, which is crucial for the promising antitumour activity of doxorubicin-related therapy, is governed by two inseparable processes: intercellular diffusion and intracellular retention.

A long

Purpose In order to investigate the long-term fate of the herbicide chloridazon and its polar metabolites desphenyl-chloridazon and methyl-desphenyl-chloridazon, a lysimeter experiment was conducted. Materials and methods The plant protection product Pyramin WG, which contains chloridazon, was applied to a weighable, monolithic lysimeter and a backfilled, gravitation lysimeter. Leachate, soil

Drug Diffusion

In Pocket Companion to Brenner and Rector's The Kidney (Eighth Edition), 2011Factors Affecting Clearance Drug removal by conventional hemodialysis occurs primarily by the process of drug diffusion across the dialysis membrane and is most effective for drugs that less than 500 Da and less than 90% protein bound with a small volume of distribution.

A novel individual

Background and purpose: Effective drug delivery in the avascular regions of tumours, which is crucial for the promising antitumour activity of doxorubicin-related therapy, is governed by two inseparable processes: intercellular diffusion and intracellular retention.

Rapid Identification of Tanshinone IIA Metabolites in an

Consequently, a total of 37 metabolites were positively or putatively identified on the basis of mass fragmentation behavior, accurate mass measurements and retention times. As a result, methylation, hydroxylation, dehydration, decarbonylation, reduction reaction, glucuronidation, glycine linking and their composite reactions were characterized to illuminate metabolic pathways of tan IIA in vivo.

Influence of ultrasound

2019/11/1The effective solute diffusion coefficient influenced by many factors like temperature, osmotic condition, moisture ratio and structure of food, . Table 1 . Influence of ultrasound assisted osmotic dehydration on antioxidant, phenolics and diffusion coefficient of plum.

Diffusion in Biofilms

Much of what makes life in a microbial biofilm different from life in a free aqueous suspension can be explained by invoking the phenomenon of diffusion. This article discusses the profound influence of the physics of the diffusion process on the chemistry and biology

The Metabolic Responses to Aerial Diffusion of Essential Oils

2012/9/12Anxiety disorders are the most prevalent psychiatric disorders and affect a great number of people worldwide. Essential oils, take effects through inhalation or topical application, are believed to enhance physical, emotional, and spiritual well-being. Although clinical studies suggest that the use of essential oils may have therapeutic potential, evidence for the efficacy of essential oils in

Diffusion in Brain Extracellular Space

2008/10/1An earlier model of restricted diffusion, using a less sophisticated pore model along with an attempt to incorporate interstitial viscosity, had been described by Rusakov and Kullmann (). It remains an important question for future theoretical research to further reconcile these various models or to develop new ones to account for the expanding database of experimental results.

A review of retention mechanism studies for packed

However, the proposed model could not predict accurately the retention of the sorbed analytes at low reduced densities and fast flow rates, which might be caused by the impact of the axial distribution of the external porosity. 72 Later work from Leśko et al 2 /5%

Minerals

This research combines a centrifugal test and nuclear magnetic resonance (NMR) technology to study the water retention capacity of the cemented paste backfill. Backfill samples with cement–tailings ratios of 1:4, 1:8, and 1:12, and solid concentrations of 71%, 74%, 77%, 80%, and 83% respectively, were prepared for the test. The relative centrifugal force ( RCF ) required for accurate testing

Recent applications of retention modelling in liquid

The model was extrapolated to predict retention in case cooling was employed. This model will be further discussed in Section 3.4.2. Chang et al. used the retention parameters of the LSS and ADS model for their peak‐picking algorithm []. Clustering based on

Early Detection of Recurrent Breast Cancer Using

Nevertheless, the model based on 11 metabolites had the best performance and clearly outperformed the accepted monitoring assay, CA 27.29, currently used for monitoring patients (). These results promise a significant improvement for early detection and potentially better treatment options for

Pulmonary absorption

2018/3/1A tissue retention compartment was needed in the computational model to describe the drug transport profiles in the IPL model for most (16 of 19) of the investigated APIs. This indicates that the majority of compounds were retained to some extent in the lungs, which was one of the main objectives of this study to investigate.

Pulmonary absorption

2018/3/1A tissue retention compartment was needed in the computational model to describe the drug transport profiles in the IPL model for most (16 of 19) of the investigated APIs. This indicates that the majority of compounds were retained to some extent in the lungs, which was one of the main objectives of this study to investigate.

A long

Purpose In order to investigate the long-term fate of the herbicide chloridazon and its polar metabolites desphenyl-chloridazon and methyl-desphenyl-chloridazon, a lysimeter experiment was conducted. Materials and methods The plant protection product Pyramin WG, which contains chloridazon, was applied to a weighable, monolithic lysimeter and a backfilled, gravitation lysimeter. Leachate, soil

Mass transfer and metabolic reactions in hepatocyte

The improved viability predicted by the model culturing hepatocyte spheroids in the RWMS, characterized by a higher O(2) permeability with respect to RWPS, was experimentally confirmed. The results demonstrated that the mathematical model used in this study represents a useful support to experimental procedures in order to obtain hepatocyte spheroids with optimal size.

Identification and antimicrobial activity of most

2018/6/5Solanum nigrum and C. sativa extracts demonstrated a certain antimicrobial activity, while A. rusticana did not reveal any activity against bacteria in this research. The Gram− bacteria, P. orientalis and S. maltophilia, were sensitive only to the S. nigrum extract, showing a middle inhibition diameter of 13.5 and 15 mm, respectively; moreover, this extract proved a middle antimicrobial

Fatty acid binding protein is a major determinant of

A slow-diffusion/bound model was found to better describe the hepatic disposition of unchanged [3 H] A major finding in this study is that both the production of low-molecular-weight metabolites of palmitate and retention of palmitate metabolites by the liver

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